Matrix effect of metal elements in inductively coupled plasma mass spectrometry
LIU Shu1, GAN Zhaoxiang1,2, MIN Hong1
1. Technical Center for Industrial Product and Raw Material Inspection and Testing of Shanghai Customs, Shanghai 200135, China; 2. Chemical Engineering and Biotechnology, Key Laboratory of Science and Technology of Eco-Textile, Ministry of Education, Donghua University, Shanghai 201620, China
Abstract：Inductively coupled plasma mass spectrometry (ICP-MS) is the most important method for the detection of trace elements. However, the matrix effect restricts its application in complex matrix samples. The generation mechanism of matrix effect of metal elements was summarized, including ionization suppression, space charge effect and synergistic effect. Among them, the synergistic effect could better explain the matrix interference under different conditions, which has been recognized by more and more researchers. The matrix interference in the detection of trace elements in alkali metal, alkaline earth metal, iron and copper matrix was discussed. The high concentration of metal matrix might lead to the blockage of sampling cone, leading to the irregular loss of signal and the deterioration of analysis accuracy. It might also inhibit the signal of some elements to be measured, resulting in lower determination results. The common elimination or correction methods of matrix effect were summarized, including the optimization of instrument hardware, the optimization of instrumental testing parameters, the optimization of calibration method and chemical separation. It can provide reference for the accurate determination of trace elements in metal matrix.
刘曙, 干兆祥, 闵红. 电感耦合等离子体质谱分析中金属元素的基体效应[J]. 冶金分析, 2021, 41(12): 79-85.
LIU Shu, GAN Zhaoxiang, MIN Hong. Matrix effect of metal elements in inductively coupled plasma mass spectrometry. , 2021, 41(12): 79-85.
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