Discussion on collision/reaction cell conditions for determination of trace iron by inductively coupled plasma mass spectrometry
WANG Zheng1, ZHAO Xue-hong*1,2, SUN Chuan-qiang1, WANG Yan1,2
1. School of Precision Instrument and Opto-electronics Engineering, Tianjin University, Tianjin 300072, China;
2.Tianjin Key Laboratory of Biomedical Detecting Techniques and Instruments, Tianjin 300072, China
The determination of trace iron by inductively coupled plasma mass spectrometry (ICP-MS) was seriously interfered by polyatomic ion ArO+. Such interference could be effectively eliminated by the collision/reaction cell technology. In this paper, the working parameters of collision/reaction cell were investigated to improve the detection ablity of iron by ICP-MS. The effect of several experimental factors on the elimination of ArO+ interference was discussed, including six types of quadrupole collision/reaction cell gases (NH3, He, H2, N2O, He-H2 and He-NH3), the flow rate of gas, the collision/reaction cell RPq value, the collision/reaction cell offset (CRO) and quadrupole mass analyzer rod offset (QRO). The optimal parameters of collision/reaction cell were obtained. The experimental results indicated that the detection limit of iron was lowest when 0.3 mL/min NH3-1.3 mL/min He mixed gas was selected as the collision/reaction cell gas. The optimized RPq value was 0.5 under different gas conditions. The optimized value of CRO and QRO under collision mode were -17 V and -7 V, respectively, and they were -1 V and -11 V respectively both under reaction mode and mixed gas mode. The detection limit of iron under optimized conditions was 14 ng/L.
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